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Kadamba Peptides

Kadamba Peptides

Kadamba Peptides are commonly Known as Katti peptides, named by the National Academy of Inventors USA, recognizing the discoverer Professor Kattesh V. Katti (from the University of Missouri, USA), who is a pioneer in the field of nanomedicine and green nanotechnology, refer to a class of peptides comprising of trimeric amino acids. These trimeric amino acids are unique because they mimic three dimensional morphology—similar to various cellular and protein structures in living organisms (Figure 3). Such three-dimensional sequences and structures are aimed to achieve targeted therapeutic effects and improved delivery mechanisms in a myriad of biomedical and nanoceutical applications.

Kadamba peptides comprise of synthetic and naturally derived amino acids engineered in three-dimensional frameworks to enhance the delivery and efficacy of therapeutic agents, particularly in the context of amino acid-based nutraceuticals, therapeutic agents and nanomedicine agents. Kadamba peptides leverage the principles of green nanotechnology to minimize environmental impact and enhance biocompatibility.

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Kadamba peptides represent a promising class of three-dimensional amino acids serving as important building blocks in synthetic and structural peptide and protein science. The interplay and various combinations of amino acid sequences offer new opportunities in drug design and nutritional science for targeted delivery and enhanced therapeutic efficacy. Their ability to serve as reservoirs of essential amino acids make them valuable tools in the advancement of personalized medicine for sustainable healthcare solutions. The potential applications of Kadamba peptides are expected to expand the horizons of medicine and nutritional science thus providing innovative and unprecedented solutions to complex medical challenges.

Advantages

Biocompatibility

Designed to be highly biocompatible, reducing the risk of adverse reactions.

Environmental Friendliness

Synthesized using green chemistry principles, minimizing environmental impact.

Versatility

Can be tailored for a wide range of applications, from drug delivery to diagnostic imaging.

Targeted Action

High specificity for target tissues or receptors enhances therapeutic efficacy and reduces off-target effects.

Uniqueness

Target Specificity

Katti peptides are designed with sequences that target specific receptors or tissues, ensuring precise delivery of therapeutic agents.

Stability

Incorporation of non-natural amino acids or modifications to enhance stability and resistance to proteolytic degradation.

Therapeutic Activity

Peptides may have inherent biological activity, such as antimicrobial, anti-inflammatory, or anticancer effects.

Imaging Agents

Used in MRi scans, they enhance image contrast,aiding in the diagonsis of various medical conditions.

Applications in Nanomedicine

Applications in Nanomedicine

Enhanced ability to cross biological barriers such as the blood-brain barrier, improving the delivery of therapeutics to hard-to-reach tissues.

Nanocarriers

Katti peptides can be conjugated to nanoparticles to improve the delivery of drugs, ensuring targeted and sustained release.

Anticancer Peptides

Target specific cancer cell markers to deliver cytotoxic agents or modulate the immune response against tumours

Applications in Nanomedicine

Enhanced ability to cross biological barriers such as the blood-brain barrier, improving the delivery of therapeutics to hard-to-reach tissues.

Antimicrobial Peptides

Designed to combat bacterial infections by disrupting bacterial membranes.

Tissue Engineering

Nanoparticles functionalized with bioactive peptides facilitate tissue regeneration by promoting cellular adhesion, proliferation, and differentiation.

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